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Cruises from San Diego, California

A cruise from San Diego is the perfect way to see the delights of the Mexican Riviera to the south or further up the Californian coast along the western seaboard all the way north to Vancouver, even as a one-way trip. Alternatively, there are also many itineraries departing for round-trip sailings to Hawaii. Typically with a duration of 7 to 10 days, whether you're a couple, family or solo traveller, and with plenty of flights options out of the UK to San Diego International Airport, you'll easily find the best cruise departing San Diego for you for 2026, 2027 and 2028 with CruiseKings. Call one of our friendly Cruise Experts and book your dream San Diego cruise adventure today!

Cruises from San Diego

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    16-Day Panama Canal

    Holland America Line

    Nieuw Amsterdam 02 October 2026 16 nights

    Itinerary: San Diego - Puerto Vallarta - Santa Cruz - Puerto Chiapas - Puerto Quetzal - Acajutla - Cartagena - Half Moon Cay - Fort Lauderdale

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £2,269pp
    • Ocean View £2,339pp
    • Balcony £3,099pp

    Includes extra savings of up to £129pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 03 October 2026 7 nights

    Itinerary: San Diego - Puerto Vallarta - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £939pp
    • Ocean View £1,109pp
    • Balcony Call Us

    more details

    14 nights Alaska from San Diego

    MSC Cruises

    MSC Poesia 03 October 2026 14 nights

    Itinerary: San Diego - Cabo San Lucas - Puntarenas - Colon - Cartagena - Miami

    • Great family prices - children up to 17 years
    • Gratuities Included

    Call us now on 0800 197 8050

    more details

    7 Night Ensenada, Cabo & La Paz Cruise

    Royal Caribbean

    Serenade of the Seas 04 October 2026 7 nights

    Itinerary: San Diego - La Paz - Cabo San Lucas - Ensenada - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Ask About Kids & Teen Places from £99pp
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £349pp
    • Ocean View £359pp
    • Balcony £629pp

    more details

    7-Day Mexican Riviera

    Holland America Line

    Zaandam 08 October 2026 7 nights

    Itinerary: San Diego - Cabo San Lucas - La Paz - Mazatlan - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Call us now on 0800 197 8050

    more details

    16-Day Panama Canal

    Holland America Line

    Eurodam 08 October 2026 16 nights

    Itinerary: San Diego - Cabo San Lucas - Acapulco - Santa Cruz - Puerto Chiapas - Puerto Quetzal - Puntarenas - Oranjestad - Fort Lauderdale

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Call us now on 0800 197 8050

    more details

    35-Day Legendary Hawaii, Tahiti & Marquesas

    Holland America Line

    Zaandam 15 October 2026 35 nights

    Itinerary: San Diego - Nawiliwili - Honolulu - Kahului - Kona - Fanning Island - Rangiroa - Huahine - Bora Bora - Raiatea...

    Call us now on 0800 197 8050

    more details

    7 Night Ensenada, Cabo & La Paz Cruise

    Royal Caribbean

    Serenade of the Seas 18 October 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - La Paz - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Ask About Kids & Teen Places from £99pp
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £329pp
    • Ocean View £329pp
    • Balcony £569pp

    Includes extra savings of up to £36pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Magic 19 October 2026 5 nights

    Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £719pp
    • Ocean View £789pp
    • Balcony £979pp

    more details

    11-Day Mexican Riviera & Sea of Cortez

    Holland America Line

    Koningsdam 20 October 2026 11 nights

    Itinerary: San Diego - Manzanillo - Puerto Vallarta - Mazatlan - La Paz - Cabo San Lucas - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,479pp
    • Ocean View £1,599pp
    • Balcony £1,909pp

    Includes extra savings of up to £80pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 22 October 2026 5 nights

    Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £629pp
    • Ocean View £729pp
    • Balcony £879pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Magic 24 October 2026 6 nights

    Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £739pp
    • Ocean View £879pp
    • Balcony £1,079pp

    more details

    7 Night Ensenada, Cabo & La Paz Cruise

    Royal Caribbean

    Serenade of the Seas 25 October 2026 7 nights

    Itinerary: San Diego - La Paz - Cabo San Lucas - Ensenada - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Ask About Kids & Teen Places from £99pp
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £339pp
    • Ocean View £339pp
    • Balcony £539pp

    Includes extra savings of up to £56pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 27 October 2026 6 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - San Diego

    Cruise Only from

    • Interior £739pp
    • Ocean View £879pp
    • Balcony £1,079pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Magic 30 October 2026 7 nights

    Itinerary: San Diego - Puerto Vallarta - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £919pp
    • Ocean View £1,099pp
    • Balcony £1,359pp

    more details

    7 Night Ensenada, Cabo & Mazatlan Cruise

    Royal Caribbean

    Serenade of the Seas 01 November 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - Mazatlan - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Ask About Kids & Teen Places from £99pp
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £319pp
    • Ocean View £439pp
    • Balcony £439pp

    Includes extra savings of up to £25pp

    more details

    Eastbound Panama Canal Cruise from San Diego ending in Galveston

    Disney Cruise Line

    Disney Magic 06 November 2026 14 nights

    Itinerary: San Diego - Cabo San Lucas - Puerto Vallarta - Panama Canal - Cartagena - George Town - Galveston

    Cruise Only from

    • Interior £1,809pp
    • Ocean View £2,379pp
    • Balcony Call Us

    more details

    7 Night Ensenada, Cabo & Mazatlan Cruise

    Royal Caribbean

    Serenade of the Seas 08 November 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - Mazatlan - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Ask About Kids & Teen Places from £99pp
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £369pp
    • Ocean View £479pp
    • Balcony £479pp

    Includes extra savings of up to £25pp

    more details

    7-Day Classic California Coast

    Holland America Line

    Koningsdam 14 November 2026 7 nights

    Itinerary: San Diego - Catalina Island - San Francisco - Ensenada - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,039pp
    • Ocean View £1,119pp
    • Balcony £1,269pp

    Includes extra savings of up to £74pp

    more details

    7 Night Ensenada, Cabo & La Paz Cruise

    Royal Caribbean

    Serenade of the Seas 15 November 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - La Paz - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Ask About Kids & Teen Places from £99pp
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £349pp
    • Ocean View £429pp
    • Balcony £429pp

    Includes extra savings of up to £49pp

    more details

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