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Cruises from San Diego, California

A cruise from San Diego is the perfect way to see the delights of the Mexican Riviera to the south or further up the Californian coast along the western seaboard all the way north to Vancouver, even as a one-way trip. Alternatively, there are also many itineraries departing for round-trip sailings to Hawaii. Typically with a duration of 7 to 10 days, whether you're a couple, family or solo traveller, and with plenty of flights options out of the UK to San Diego International Airport, you'll easily find the best cruise departing San Diego for you for 2026, 2027 and 2028 with CruiseKings. Call one of our friendly Cruise Experts and book your dream San Diego cruise adventure today!

Cruises from San Diego

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    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 27 October 2026 6 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - San Diego

    Cruise Only from

    • Interior £759pp
    • Ocean View £899pp
    • Balcony £1,119pp

    more details

    Halloween on the High Seas Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Magic 30 October 2026 7 nights

    Itinerary: San Diego - Puerto Vallarta - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £949pp
    • Ocean View £1,129pp
    • Balcony £1,399pp

    more details

    7 Night Ensenada, Cabo & Mazatlan Cruise

    Royal Caribbean

    Serenade of the Seas 01 November 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - Mazatlan - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £239pp
    • Ocean View £479pp
    • Balcony £489pp

    Includes extra savings of up to £47pp

    more details

    Eastbound Panama Canal Cruise from San Diego ending in Galveston

    Disney Cruise Line

    Disney Magic 06 November 2026 14 nights

    Itinerary: San Diego - Cabo San Lucas - Puerto Vallarta - Panama Canal - Cartagena - George Town - Galveston

    Cruise Only from

    • Interior £1,869pp
    • Ocean View £2,449pp
    • Balcony £4,149pp

    more details

    7 Night Ensenada, Cabo & Mazatlan Cruise

    Royal Caribbean

    Serenade of the Seas 08 November 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - Mazatlan - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today

    Cruise Only from

    • Interior £219pp
    • Ocean View £489pp
    • Balcony Call Us

    Includes extra savings of up to £32pp

    more details

    7-Day Classic California Coast

    Holland America Line

    Koningsdam 14 November 2026 7 nights

    Itinerary: San Diego - Catalina Island - San Francisco - Ensenada - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,039pp
    • Ocean View £1,119pp
    • Balcony £1,269pp

    Includes extra savings of up to £53pp

    more details

    7 Night Ensenada, Cabo & La Paz Cruise

    Royal Caribbean

    Serenade of the Seas 15 November 2026 7 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - La Paz - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £239pp
    • Ocean View £499pp
    • Balcony £329pp

    more details

    Very Merrytime Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 16 November 2026 6 nights

    Itinerary: San Diego - Ensenada - Cabo San Lucas - San Diego

    Cruise Only from

    • Interior £749pp
    • Ocean View £879pp
    • Balcony £1,089pp

    more details

    18-Day Circle Hawaii Holiday

    Holland America Line

    Zaandam 19 November 2026 18 nights

    Itinerary: San Diego - Hilo - Kona - Kahului - Nawiliwili - Honolulu - Ensenada - San Diego

    Call us now on 0800 197 8050

    more details

    30-Day Circle Hawaii & Sea of Cortez

    Holland America Line

    Zaandam 19 November 2026 30 nights

    Itinerary: San Diego - Hilo - Kona - Kahului - Nawiliwili - Honolulu - Ensenada - San Diego - Cabo San Lucas - Loreto...

    Call us now on 0800 197 8050

    more details

    7-Day Baja Peninsula

    Holland America Line

    Koningsdam 21 November 2026 7 nights

    Itinerary: San Diego - Cabo San Lucas - La Paz - Guayamas - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,039pp
    • Ocean View £1,119pp
    • Balcony Call Us

    Includes extra savings of up to £47pp

    more details

    7 Night Cabo, Mazatlan & La Paz Cruise

    Royal Caribbean

    Serenade of the Seas 22 November 2026 7 nights

    Itinerary: San Diego - Cabo San Lucas - La Paz - Mazatlan - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today

    Cruise Only from

    • Interior £449pp
    • Ocean View £449pp
    • Balcony Call Us

    more details

    Very Merrytime Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 22 November 2026 7 nights

    Itinerary: San Diego - Mazatlan - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £1,769pp
    • Ocean View £2,129pp
    • Balcony Call Us

    more details

    10-Day Mexican Riviera & Sea of Cortez

    Holland America Line

    Koningsdam 28 November 2026 10 nights

    Itinerary: San Diego - Cabo San Lucas - La Paz - Mazatlan - Puerto Vallarta - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,379pp
    • Ocean View £1,449pp
    • Balcony £1,679pp

    Includes extra savings of up to £101pp

    more details

    Very Merrytime Mexican Riviera Cruise from San Diego

    Disney Cruise Line

    Disney Wonder 29 November 2026 5 nights

    Itinerary: San Diego - Cabo San Lucas - Ensenada - San Diego

    Cruise Only from

    • Interior £709pp
    • Ocean View £789pp
    • Balcony £1,809pp

    more details

    12-Day Historical Baja Peninsula

    Holland America Line

    Zaandam 07 December 2026 12 nights

    Itinerary: San Diego - Cabo San Lucas - Loreto - Guayamas - Topolobampo - La Paz - Mazatlan - Puerto Vallarta - Ensenada - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,659pp
    • Ocean View £1,729pp
    • Balcony Call Us

    Includes extra savings of up to £130pp

    more details

    11-Day Mexican Riviera & Sea of Cortez

    Holland America Line

    Koningsdam 08 December 2026 11 nights

    Itinerary: San Diego - Manzanillo - Puerto Vallarta - Mazatlan - La Paz - Cabo San Lucas - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,479pp
    • Ocean View £1,559pp
    • Balcony £1,829pp

    Includes extra savings of up to £107pp

    more details

    7 Nt Cabo Overnight, Catalina & Ensenada

    Royal Caribbean

    Serenade of the Seas 13 December 2026 7 nights

    Itinerary: San Diego - Catalina Island - Ensenada - Cabo San Lucas - San Diego

    • Limited Time Savings - Call Our Cruise Experts Today
    • Big Balcony Sale - Upgrade for Less

    Cruise Only from

    • Interior £299pp
    • Ocean View £319pp
    • Balcony £409pp

    Includes extra savings of up to £56pp

    more details

    7-Day Baja Peninsula Holiday

    Holland America Line

    Koningsdam 19 December 2026 7 nights

    Itinerary: San Diego - Cabo San Lucas - La Paz - Mazatlan - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £1,229pp
    • Ocean View £1,349pp
    • Balcony £1,659pp

    Includes extra savings of up to £92pp

    more details

    14-Day Mexican Riviera & Baja Peninsula Holiday

    Holland America Line

    Koningsdam 19 December 2026 14 nights

    Itinerary: San Diego - Cabo San Lucas - La Paz - Mazatlan - San Diego - Puerto Vallarta - Mazatlan - Cabo San Lucas - San Diego

    • Have It All - Beverage Package, Speciality Dining, Shore Excursion Credit, WiFi, Gratuities

    Cruise Only from

    • Interior £2,479pp
    • Ocean View £2,689pp
    • Balcony £3,319pp

    Includes extra savings of up to £182pp

    more details

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